Kakatiya Medical College was founded in 1959 by the Warangal Regional Medical Education society with the active support of the Chief Minister of Andhra Pradesh, Neelam Sanjiva Reddy, the Director of Medical Services of A.P. and the Warangal District Collector Mohsin Bin Shabbir (whose picture adorns the main entrance of the medical school with quote 'The Earth sometimes bears gems and here is one') to provide medical education for students of the Telangana region of the state.
The college was inaugurated on 23 July 1959 by the P. Karmarkar, Minister of Health, Government of India. It was originally in a building donated by the Pingale family at Waddepally and it moved into the makeshift building constructed at the permanent site in November 1961.