Jayalalithaa first came into prominence as a leading film actress in the mid-1960s. Though she had entered the profession reluctantly, upon the urging of her mother to support the family, Jayalalithaa worked prolifically. She appeared in 140 films between 1961 and 1980, primarily in the Tamil, Telugu and Kannada languages. Jayalalithaa received praise for her versatility as an actress and for her dancing skills, earning the sobriquet "Queen of Tamil Cinema".[5] Among her frequent co-stars was M. G. Ramachandran, popularly known as 'M.G.R.', a Tamil cultural icon who leveraged his immense popularity with the masses into a successful political career. In 1982, when M.G.R. was chief minister, Jayalalithaa joined the AIADMK, the party he founded. Her political rise was rapid; within a few years she became AIADMK propaganda secretary and was elected to the Rajya Sabha, the upper house of India's Parliament. After M.G.R.'s death in 1987, Jayalalithaa proclaimed herself his political heir and, having fought off the faction headed by M.G.R.'s widow, V. N. Janaki Ramachandran, emerged as the sole leader of the AIADMK. Following the 1989 election, she became Leader of the Opposition to the DMK-led government headed by M. Karunanidhi, her bête noire.
In 1991, Jayalalithaa became chief minister for the first time and Tamil Nadu's youngest. She earned a reputation for centralising state power among a coterie of bureaucrats; her council of ministers, whom she often shuffled around, were largely ceremonial in nature. The successful cradle-baby scheme, which enabled mothers to anonymously offer their newborns for adoption, emerged during this time. Despite an official salary of only a rupee a month, Jayalalithaa indulged in public displays of wealth, culminating in a lavish wedding for her foster son V. N. Sudhakaran (Sasikala's elder sister son) on 7 September 1995. In the 1996 election, the AIADMK was nearly wiped out at the hustings; Jayalalithaa herself lost her seat. The new Karunanidhi government filed several corruption cases against her, and she had to spend time in jail. Her fortunes revived in the 1998 general election, as the AIADMK became a key component of Prime Minister Atal Bihari Vajpayee's 1998–99 government; her withdrawal of support toppled it and triggered another general election just a year later.