Of the 42.42% of the city's residents who identify as religious, Roman Catholics make up the largest group, at 11.31%.[172] The second highest religious group in the city are Baptists at 10.31%, with Methodists following behind at 4.97%. Presbyterians make up 2.13% of the city's religiously affiliated population, followed by Pentecostals and Lutherans. Another 8.57% are affiliated with other Christian faiths.[172] 0.32% of religiously affiliated persons identified themselves as following Eastern religions, while 0.68% of the religiously affiliated population identified as Jewish, and 0.29% as Muslim.[172] According to the nonpartisan and nonprofit Public Religion Research Institute's American Values Atlas, 22% of residents identify as religiously "unaffiliated," consistent with the national average of 22.7%.[173]
SS. Peter and Paul Cathedral is the seat of the Roman Catholic Archdiocese of Indianapolis.[174] Bishop Simon Bruté College Seminary and Marian University are affiliated with the archdiocese. Christian Theological Seminary is another seminary located in the city, affiliated with the Christian Church (Disciples of Christ). Christ Church Cathedral, the city's oldest house of worship, is pro-cathedral of the Episcopal Diocese of Indianapolis.[175] The Indiana-Kentucky Synod of the Evangelical Lutheran Church in America is also based in Indianapolis. Religious denominations headquartered in the city include the Free Methodist Church and Lutheran Ministerium and Synod – USA.